Endocrine Abstracts

Introduction: A high prevalence of polycystic ovary syndrome (PCOS) and hyperandrogenism has been described in adult women with type 1 diabetes mellitus (T1DM). Anti-Müllerian hormone (AMH) is secreted by granulosa cells of antral ovarian follicles and its plasma concentration is correlated with the number of small antral follicles. AMH levels are increased in women with PCOS and higher plasma concentration has been observed in prepubertal girls with T1DM. The aim of this...

Introduction: Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL-6) may play a role in appetite, energy expenditure and body weight control in central nervous system. IL-6 acts through binding with membrane receptor (IL-6R) and activates glycoprotein 130 (gp130) signaling. Both IL-6R and gp130 are present in the blood in the soluble forms (sIL-6R and sgp130, respectively). sIL-6R sensitizes cells to...

Introduction: Visfatin is a protein secreted by adipose tissue which was discovered as a protein with insulin-mimetic properties. Experimental and clinical studies demonstrated that visfatin can be involved in the pathogenesis of insulin resistance. It was demonstrated that plasma visfatin is elevated in insulin resistant states i.e. obesity, type two diabetes mellitus, PCOS. In vitro study showed that insulin inhibits visfatin release from adipocytes. The aim of the pr...